Serum 25-hydroxy Vitamin D levels as an Indicator of Bone Mineral Density in Osteoporosis
Published: August 1, 2018 | DOI: https://doi.org/10.7860/JCDR/2018/35447.11919
P Modagan, Santhi Silambanan, Gopinath Menon, P Arunalatha
1. Ph.D. Scholar, Department of Biochemistry, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.
2. Professor and Head, Department of Biochemistry, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.
3. Professor and Head, Department of Orthopaedics, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.
4. Professor and Head, Department of Pathology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.
Correspondence
Dr. P Modagan,
Ph.D. Scholar, Department of Biochemistry, Sri Ramachandra Medical College and Research Institute,
Chennai-600116, Tamil Nadu, India.
E-mail: pmodagan@gmail.com
Introduction: Osteoporosis is a silent disease; the complications of disease are, an increased risk of fractures resulting in major health and economic impact. The 25-hydroxy vitamin D {25(OH) vitamin D} deficiency linked with osteoporosis and has been related to the low Bone Mineral Density (BMD).
Aim: The aim was to evaluate the 25(OH) vitamin D status and BMD in osteoporosis and to compare the status of vitamin D and BMD in osteoporosis group with normal control and osteopenia group.
Materials and Methods: A total of 90 subjects in the age group between 30 to 90 years of both sexes were included in the study. They were grouped into three, based on DEXA T-score of BMD as Group I -Normal bone mass, Group II-Osteopenia and Group III-Osteoporosis. The anthropometric data were measured and biochemical parameters were analysed for calcium, phosphorus and 25 (OH) vitamin D. One-way ANOVA was used for statistical interpretation.
Results: Statistical significant difference was observed in BMD at neck of femur (p<0.001), BMD at lumbar spine (p<0.001), 25(OH) vitamin D (p=0.009) and calcium (p=0.003) when compared between the three groups. In this study the 25(OH) vitamin D deficiency was higher in osteoporosis 19(63.3%) and the insufficiency was higher in osteopenia 13(43.3%) compared with other groups.
Conclusion: Decreased BMD performs a central role in the development of osteoporosis. The 25 (OH) vitamin D deficiencies may suggest the interrelation between bone remodeling disturbances in osteoporosis. The study shows that the 25(OH) vitamin D concentrations indicate the bone mineral status and thus the extent of the disease.
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